The results for mutations in the RET gene can help to identify the risk for medullary carcinoma in a patient with the MEN2 syndrome.
Parameters:
(1) type of MEN2 syndrome
(2) RET codon with mutation
Type of MEN2
RET codon
Risk Group
MEN2B
NA
highest (Level 3)
883, 918, 922
MEN2A
611, 618, 620, 634
high (Level 2)
609, 768, 790, 791, 804, 891
Level 1
Timing of Total Thyroidectomy
Level 3
ideally within 1 month of birth; no later than 6 months of age
Level 2
before 5 years of age
varied recommendations (by 5 years of age, by 10 years of age, based on pentagastrin stimulated calcitonin test)
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Specialty: Hematology Oncology, Genetics, Surgery, general
