Some men who use testosterone may suffer a thromboembolic event. Some of these patients may have an underlying thrombophilia which may have gone unrecognized.
Thrombotic events may include:
(1) acute myocardial infarction
(2) stroke
(3) deep vein thrombosis
(4) pulmonary embolism
(5) amaurosis fugax
(6) osteonecrosis
If a man who is taking testosterone has an unexplained thrombosis, then he should be evaluated for a hypercoagulable state.
If a man is to be started on testosterone then he should be screened for evidence of a hypercoagulable state (Factor V Leiden, prothrombin gnee mutation, homocysteine).
If a man has a history of significant cardiovascular disease, then the risk of testosterone should be seriously considered before starting the therapy.
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