A patient with exercise-induced rhabdomyolysis may have an underlying risk for malignant hyperthermia. It is important to identify such a patient prior to anesthesia. In addition, a patient with a history of malignant hyperthermia may be at increased risk for exercise-induced rhabdomyolysis.

Patient selection: exercise-induced rhabdomyolysis


Findings which may suggest an underlying predisposition to malignant hyperthermia:

(1) family members with a history of malignant hyperthermia

(2) previous episodes of exercise-induced rhabdomyolysis and/or heat stroke

(3) severity of rhabdomyolysis episode excessive for the triggering episode


A patient who is suspected of having malignant hyperthermia should be tested for mutations in the ryanodine receptor gene (RYR1).

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