Patient selection: acute leukemia with Pseudomonas aeruginosa bloodstream infection
Mortality rate if not multi-drug resistant: 5.5%
Mortality rate if multi-drug resistant: 29%
66% of patients with multi-drug resistant Pseudomonas aeruginosa received inappropriate empirical antibiotic therapy in the first 48 hours after onset.
Risk factors for multi-drug resistance on multivariate analysis:
(1) therapy with quinolones (OR 5.9)
(2) therapy with piperacillin/tazobactam (OR 2.8)
Risk factors for mortality within 30-days:
(1) multi-drug resistant Pseudomonas aeruginosa bloodstream infection (OR 7.2)
(2) perianal infection (OR 4.1)
(3) pulmonary infection (OR 3.0)
(4) age >= 55 years (OR 2.9)