Risk Factors of Zaoutis et al for Candidemia in a Pediatric Patient in the Pediatric Intensive Care Unit

 

Mortality in children with candidemia was 44% vs 14% in controls.

 

Major risk factors (odds ratio 30):

(1) central venous catheter

 

Intermediate risk factors (odds ratios 3.5 to 6.2):

(1) presence of a malignancy

(2) use of vancomycin for 4 or more days during the past 2 weeks

(3) use of antibiotics active against anaerobic bacteria for 4 or more days during the past 2 weeks

 

Additional risk factors (odds ratio 2 to 3)

(1) use of vancomycin for 1 to 3 days during the past 3 weeks

(2) receipt of total parenteral nutrition

 

Patients with a > 10% risk for candidemia:

(1) central venous catheter + malgianncy + vancomycin 4+ days (11% risk)

(2) central venous catheter + 3 or 4 of the other risk factors (12 to 46%) with the highest risk seen when all of the risk factors are present