Yokoyama et al identified risk factors for venous thromboembolism in Japanese patients with diffuse large B-cell lymphoma (DLBCL). These can help to identify a patient who may benefit from interventions to reduce thromboembolic risk. The authors are from Keio University and Waseda University in Tokyo.


Patient selection: Japanese patient with diffuse large B-cell lymphoma (DLBCL)


The key risk factor for venous thromboembolism was the ECOG status, with risk increased for ECOG stages 2, 3 and 4. The risk tended to increase as the patient became more debilitated and bed-ridden.


Additional risk factors discussed:

(1) age >= 60 years

(2) presence of a central venous catheter

(3) venous compression by the bulky lymphoma

(4) elevated serum LDH


A patient with one or more risk factors (especially high ECOG stage) may benefit from more aggressive management.


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