Risk Factors of Yang et al for Cognitive Impairment in a Patient with Amyotrophic Lateral Sclerosis (ALS)

Patient selection: amyotrophic lateral sclerosis (ALS)

Predictors of cognitive impairment:

(1) C9orf72 (OR 3.6)

(2) dysarthria (OR 2.3)

(3) family history of ALS (OR 1.8)

(4) predominant upper motor neuron phenotype (OR 1.7)

(5) bulbar onset (OR 1.5)

Predictors of frontotemporal dementia:

(1) C9orf72 (OR 5.9)

(5) bulbar onset (OR 2.1)

Predictors of executive function impairment:

(1) female sex (OR 1.8)