Wu et al reported risk factors for poor peripheral blood stem cell (PBSC) mobilization. This can help to identify a patient who may have a low CD34+ cell yield. The authors are from Taipei Veterans General Hospital, University of Taipei, University of North Carolina at Chapel Hill and Saint Mary's Hospital in Luodong, Taiwan.
Patient selection: underlying malignancy
Outcome: poor stem cell mobilization
Parameters:
(1) age in years
(2) underlying malignancy
(3) history of radiotherapy
(4) number of previous chemotherapy cycles
(5) mobilization regimen
Parameter
Finding
Points
age in years
< 60 years of age
0
>= 60 years of age
1
underlying malignancy
leukemia, lymphoma, myeloma
0
solid tumor
1
history of radiotherapy
no
0
yes
1
number of previous chemotherapy cycles
< 5
0
>= 5
1
mobilization regimen
G-CSF only
1
high dose cyclophosphamide
1
other
0
number of risk factors for poor harvest =
= SUM(points for all 5 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 5
• A score >= 3 is associated with poor stem cell mobilization.
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