von Rotz et al identified factors associated with premature ventricular contractions (PVCs) in healthy young adults. The authors are from multiple institutions in Europe and North America.

Patient selection: apparently healthy young adults (some of the risk factors suggest that there may occult disease)


Outcome: premature ventricular contractions (PVCs)


Risk factors for PVCs include:

(1) low educational status

(2) body height above the median

(3) obesity (high waist to hip ratio)

(4) elevated serum NT-proBNP

(5) low physical activity

(6) anemia

(7) low serum glucagon-like peptide-1

(8) high Sokolow-Lyon index (a measure of left ventricular hypertrophy)


A patient with multiple risk factors may benefit from screening and interventions to reduce the risk.


Other factors that may impact risk:

(1) cigarette smoking

(2) older age

(3) high intake of fruits and vegetables

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