Velayos et al identified factors affecting the risk of colorectal carcinoma in a patient with ulcerative colitis. This can help identify ways to reduce the risk of cancer in these patients or to detect it at an early stage. The authors are from the University of California San Francisco, Mayo Clinic, and Herlev University Hospital in Denmark.


Factors increasing the risk of colorectal cancer:

(1) history of pseudopolyps

(2) family history of colorectal carcinoma


Factors reducing the risk of colorectal cancer:

(1) 2 or more surveillance colonoscopies

(2) chronic use of aspirin or other NSAIDS

(3) cigarette smoking

(4) corticosteroid therapy

(5) therapy with 5-aminosalicylic acid (not statistically significant if > 5 years)


Factors found not to be statistically significant:

(1) primary sclerosing cholangitis

(2) immunosuppressive therapy



• The protection offered by surveillance colonoscopy was theorized to be due to early diagnosis of dysplastic change with subsequent colectomy.


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