Tselios et al reported risk factors for rapid progression of lupus nephritis to end-stage renal disease. These can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Toronto and University Health Network Toronto.
Patient selection: lupus nephritis
Outcome: rapid progression of renal disease (rate of decline >= 20 mL per min per 1.73 square meter per year)
Frequency: uncommon (around 2%)
Risk factors for rapid progression:
(1) poor compliance
(2) histologic features
(2a) thrombotic microangiopathy
(2b) collapsing glomerulopathy
(2c) severe interstitial inflammation
(2d) severe interstitial fibrosis and tubular atrophy (IFTA)
