Toruner et al identified risk factors for an opportunistic infection in a patient with an inflammatory bowel disease (IBD). These can help to identify a patient who may benefit from closer monitoring and early treatment. The authors are from the Mayo Clinic, Centre Hospitalier Regional Universitaire De Lille (France) and National University of Ireland (Galway).


Patient selection: Crohn's disease or ulcerative colitis


Outcome: opportunistic infection (viral, bacterial, fungal, other)


Risk factors for opportunistic infection:

(1) therapy with immunosuppressive medication(s)

(2) age > 50 years (odds ratio 3)


Immunosuppressive medications:

(1) corticosteroids

(2) azathioprine/6-mercaptopurine

(3) infliximab (or other targeted agent)


The odds of an opportunistic infection was 3 with one of these drugs and 15 with 2 or 3 of them.


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