Risk Factors of Tomlinson et al for Premature Mortality in a Patient with Hypopituitarism

Description

Tomlinson et al identified risk factors for premature mortality in patients with hypopituitarism. This can help identify patients who may benefit from closer monitoring and more aggressive management. The authors are from the University of Birmingham and the West Midlands Prospective Hypopituitary Study Group.

Causes for premature death:

(1) cardiovascular disease

(2) respiratory disease

(3) cerebrovascular disease

Parameters:

(1) age at diagnosis

(2) gender

(3) cause of the hypopituitarism

(4) therapy for gonadotropin deficiency

Parameter	Finding	Points
age of the patient	< 40 years of age	0
	40 - 60 years of age	1
	> 60 years of age	2
gender of the patient	male	0
	female	1
cause of the hypopituitarism	craniopharyngioma	1
	other cause	0
gonadotropin deficiency	absent	0
	present and untreated	1
	present and treated	0

risk score for premature death =

= SUM(points for all 4 parameters(

Interpretation:

• minimum risk score: 0

• maximum risk score: 5

• The risk of premature death increases as the number of risk factors increases.

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Description

Specialty

ICD-10