Description

Tai et al identified risk factors for mortality in patients with acute cholangitis. This can help identify patients who may benefit from more aggressive management. The authors are from Chang Gung Memorial Hospital and Kaohsiung Medical Center in Taiwan.


 

Parameters:

(1) serum creatinine

(2) serum total bilirubin (part of Charcot's triad)

(3) bile duct stricture

(4) biliary tract stones

 

Parameter

Finding

Points

serum creatinine

< 1.5 mg/dL

0

 

>= 1.5 mg/dL

1

serum total bilirubin

not elevated

0

 

elevated

1

stones

in both the common and intrahepatic bile ducts

1

 

not in both

0

bile duct stricture

absent

0

 

present

1

 

where:

• The type of stricture is not specified. Some of the previous scores mentioned malignant strictures as a risk factor.

• The level for an elevated bilirubin was not specified. One approach is to use clinical jaundice. Another is to use a cutoff like > 5.3 or > 5.4.

 

total number of risk factors associated with mortality =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 4

 

Mortality based on clinical pattern:

(1) Reynold's pentad (Charcot's triad + hypotension + altered mental status): 21%

(2) Charcot's triad (fever + jaundice + RUQ tenderness) alone: 8%

(3) neither: 1%

 

Risk factors for an elevated serum creatinine:

(1) advanced age

(2) low serum albumin

(3) delay in biliary tract drainage

(4) clinical deterioration with multi-organ failure

 


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