Patient selection: adult undergoing ECMO therapy
Outcome: infection
Sites of infection include:
(1) bloodstream
(2) pneumonia
(3) surgical site
(4) urinary tract
Risk factors for infection:
(1) increased duration of ECMO therapy (odds ratio 1.003): duration in patients with infection from 123 to 597 hours (mean 360); duration in patients without infection associated with use 0 to 320 hours (mean 157); will use > 300 hours in the implementation
(2) mechanical complications (odds ratio 4.8): oxygenator failure, pump malfunction, heater dysfunction, clotting, connector crack, etc
(3) autoimmune disease (odds ratio 7.0): SLE, Wegener's, dermatomyositis, etc
(4) venovenous mode (odds ratio 4.5)
The risk of infection increases with the number of risk factors present.
