Stam listed risk factors for thrombosis of a cerebral vein or sinus. The author is from the University of Amsterdam.


Risk factors for thrombosis of a cerebral vein or sinus:

(1) dehydration

(2) cancer-associated hypercoagulability

(3) cancer of the head and neck

(4) oral contraceptives

(5) asparaginase

(6) head trauma

(7) trauma to the sinuses

(8) trauma to the jugular vein

(9) jugular vein catheterizaton

(10) neurosurgery

(11) lumbar puncture (although the risk may be associated with why the LP was performed)

(12) secondary polycythemia

(13) polycythemia (primary or secondary)

(14) essential thrombocythemia

(15) other myeloproliferative disorder

(16) leukemia

(17) paroxysmal nocturnal hemoglobinuria (PNH)

(18) hemoglobinopathy

(19) systemic lupus erythematosus (SLE), especially with lupus anticoagulant

(20) Wegener's granulomatosus

(21) sarcoidosis

(22) Crohn's disease or ulcerative colitis (inflammatory bowel disease)

(23) Behcet's syndrome

(24) other cause of cerebral vasculitis

(25) otitis or mastoiditis

(26) sinusitis, especially with mucormycosis

(27) meningitis

(28) systemic infectious disease

(29) nephrotic syndrome (with low protein S, protein C and/or antithrombin III)

(30) antiphospholipid antibody syndrome

(31) homocysteinemia

(32) pregnancy or puerperium

(33) antithrombin III deficiency

(34) protein C deficiency

(35) protein S deficiency

(36) Factor V Leiden mutation

(37) prothrombin gene mutation (G20210A)

(38) methylenetetrahydrofolate reductase mutation (with homocysteinemia)

(39) other cause of hypercoagulability


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