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Risk Factors of Rzany et al for Mortality in Patients with Bullous Pemphigoid Requiring Hospitalization

Description

Rzany et al identified risk factors associated with death in patients with severe bullous pemphigoid. These can help identify a patient who may require more aggressive therapy and closer monitoring. The authors are from multiple dermatology departments from Germany.


 

Risk factors associated with death:

(1) age > 80.4 years

(2) glucocorticosteroid dosage > 37 mg per day at discharge after first hospitalization

(3) serum albumin <= 3.6 g/dL

(4) duration of disease before first hospitalization < 50 days

(5) male gender

(6) erythrocyte sedimentation rate (ESR) > 30 mm/h

 

Risk Factors for Death Within 1 Year of First Hospitalization

Relative Risk (with 95% Confidence Interval)

age > 80.4 years

3.2 (1.9 – 5.2)

glucocorticosteriod dose > 37 mg per day

2.5 (1.5 – 4.3)

serum albumin <= 3.6 g/dL

2.6 (1.5 – 4.4)

duration < 50 days before hospitalization

1.5 (0.9 – 2.4)

ESR > 30 mm/h

1.7 (1.1 – 2.8)

from Table 2, page 907

 

where:

• In the implementation I considered age, steroid dose and serum albumin as major risk factors, with duration and ESR as minor risk factors.

 

Risk Factors for Death From 1 – 3 Years After First Hospitalization

Relative Risk (with 95% Confidence Interval)

age > 80.4 years

4.8 (2.6 – 9.1)

glucocorticosteriod dose > 37 mg per day

2.1 (1.1 – 4.2)

 

 

Risk Factors for Death > 3 Years After First Hospitalization

Relative Risk (with 95% Confidence Interval)

age > 80.4

2.2 (1.2 – 4.3)

male gender

1.8 (0.9 – 3.1)

 


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