Description

Ruiz-Hernandez et al identified risk factors associated with mortality for a patient with a pyogenic liver abscess. These can help to identify a patient who may benefit from more aggressive management. The authors are from Hospital Universitario de Gran Canaria.


 

Sepsis and/or septic shock was an independent risk factor for mortality on logistic regression analysis, although the rate of bacteremia was low.

 

Additional factors associated with increased mortality:

(1) older age (survivors had a mean age of 63 years vs 73 for nonsurvivors)

(2) history of coronary artery disease

(3) absence of fever

(4) jaundice

(5) biliary or cryptogenic origin (intra-abdominal had a p value of 0.056)

(6) infection with E. coli or a Candida species

(7) pneumonia

 

where:

• Although the text indicates hyperbilirubinemia is a risk factor, 66% of people who survived had a total serum bilirubin > 2.2 mg/dL vs 63% of nonsurvivors.

• Other origins for infection were intra-abdominal and hematogenous.

• The p value for a serumc creatinine > 2 mg/dL was 0.08.

• The presence of multi-organ failure would be expected to increase mortality. Sepsis or septic shock may be used synonomously with the sepsis syndrome. This also may explain the low rate of bacteremia observed.

• Serum albumin was listed in Table 1 but not Table 3.

 

Risk factors associated with complications:

(1) absence of fever

(2) hyperbilirubinemia (3.1 mg/dL vs 0.8 mg/dL)

(3) higher serum creatinine

(4) larger abscess (7.7 cm vs 4.8 cm)

 


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