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Risk Factors of Rosenberg and Hutcheson for Pediatric Sickle Cell Retinopathy

Description

Rosenberg and Hutcheson identified risk factors for pediatric sickle cell retinopathy. This can help to identify a patient who may benefit from more aggressive management. The authors are from the Children's National Medical Center in Washington, D.C.


Patient selection: sickle cell disease

 

Outcome: proliferative retinopathy

 

Risk for pediatric proliferative retinopathy:

(1) hemoglobin SC > hemoglobin S-beta-thalassemia > hemoglobin SS

(2) pain crisis

(3) splenic sequestration

(4) possibly G6PD deficiency

 

Screening recommendations:

(1) Start as 10 years of age. Consider earlier with hemoglobin SC or the presence of 2 or more risk factors.

(2) Perform a dilated fundoscopic exam.

(3) Schedule biennial during adolescence if exam normal and no risk factors, or consider annual if risk factors present.

(4) Perform fluorescein angiography if abnormal.


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