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Risk Factors of Roldan-Masedo et al for Gentamicin-Resistant Escherichia coli Urinary Tract Infection (UTI) in Children

Description

Gentamicin is frequently used to treat pediatric urinary trract infections caused by Escherichia coli. Roldam-Masedo et al identified risk factors for gentamicin-resistance in E coli causing community-acquired urinary infections. The authors are from Autonoma University and Hospital La Paz in Madrid.


Patient selection: age < 14 years with community-acquired urinary tract infection

 

Outcome: gentamicin-rersistant strain

 

Risk factors for gentamicin resistance:

(1) chronic conditions, including fecal or urinary incontinence and genitourinary malformations

(2) received antibiotic prophylaxis in the previous 6 months

 

Isolated strains could also show:

(1) cefuroxime resistance

(2) cefotaxime resistance

(3) fluoroquinolone resistance

(4) extended-spectrum beta lactamase (ESBL)

 

All isolates were susceptible to amikacin.


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