Risk Factors of Reincke et al for Decreased Renal Function in a Patient with Primary Aldosteronism

 

Patient selection: primary aldosteronism

 

Outcome: decline in glomerular filtration rate (GFR)

 

Risk factors associated with a decline in renal function in an untreated patient:

(1) advancing age (there is a progressive decline with age, will use >= 60 years in the implementation)

(2) male gender

(3) low serum potassium (marker of disease activity)

(4) high serum aldosterone concentration (marker of disease activity)

 

Therapeutic interventions associated with a decline in renal function

(1) adrenalectomy

(2) therapy with spironolactone