Description

Rautaharju et al identified risk factors in an ECG from a postmenopausal woman that are associated with increased cardiovascular mortality. These can help identify a woman who may benefit from closer monitoring and more aggressive management. The authors are from Wake Forest University in Winston-Salem, North Carolina, and the Fred Hutchinson Cancer Center in Seattle, Washington.


 

Parameters:

(1) QRS/T wave angle

(2) changes of acute myocardial infarction (AMI)

(3) QRS nondipolar voltage

(4) heart rate variability

(5) QT interval

(6) history of cardiovascular disease

Parameter

Finding

Points

QRS/T wave angle

0 to 96 degrees

0

 

wide (>= 97 degrees)

1

ECG changes of AMI

absent

0

 

present

1

QRS nondipolar voltage

< 65 microvolts

0

 

increased (>= 65 microvolts)

1

heart rate variability

>= 8 milliseconds

0

 

< 8 milliseconds (low)

1

QT interval and history of cardiovascular disease

QT interval < 437 milliseconds OR history of cardiovascular disease

0

 

QT interval prolonged (>= 437 milliseconds) AND no history of cardiovascular disease

1

 

where:

• The odds ratios for the risk factors are in the 1.8 to 2.1 range.

• The risk appears to be from all cause cardiovascular mortality (not just coronary heart disease).

• ECG changes of AMI may range from small to massive infarct, which would affect mortality.

 

total number of risk factors =

= SUM(points for all 5 risk factors)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: in theory 5, in practice probably 4

• The risk of cardiovascular mortality increases as the number of risk factors increase.

 


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