Radovancevik et al evaluated cardiac transplants for risk factors associated with accelerated coronary artery disease. These can help identify interventions that can reduce the risk of angina and myocardial infarction. The authors are from the Texas Heart Institute in Houston.


Risk factors associated with advanced coronary artery disease:

(1) cigarette smoking

(2) arterial hypertension

(3) 2 or more episodes of allograft rejection


Interventions to reduce the risk of coronary artery disease:

(1) Discontinue any tobacco use.

(2) Control arterial hypertension.

(3) Control of hyperlipidemia.


Hypercholesterolemia was not identified as a risk factor but the criteria for diagnosis is higher than that used today. Hypercholesterolemia was defined as one or more of the following:

(1) total cholesterol > 240 mg/dL

(2) LDL cholesterol > 160 mg/dL

(3) triglycerides > 250 mg/dL


To read more or access our algorithms and calculators, please log in or register.