Perlman et al reported risk factors for late onset sepsis for neonates in the hospital. These can help to identify patients who may benefit from more aggressive management. The authors are from Columbia University and New York Presbyterian Hospital.

Patient selection: neonate in the hospital


Outcome: late onset bloodstream bacterial infection (onset > 48 hours after delivery)


General risk factors:

(1) low birth weight (< 1,500 grams, with greater risk if < 1,000 grams)

(2) being in the NICU for > 24 hours

(3) presence of a central venous catheter (CVC)


Additional risk factors for catheter-related infection:

(1) total parenteral nutrition

(2) ventilator use

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