Description

Pepin et al studied patients who developed central line-associated bloodstream infections (CLABSI) in the intensive care unit (ICU). They identified a number of risk factors for CLABSI, focusing on comorbid conditions. The authors are from the University of Maryland and the Baltimore VA Medical Center.


Patient selection: age >= 18 years with central line catheter

 

Factors associated with increased risk of CLABSI:

(1) greater number of central line days

(2) kidney disease

(3) beta blocker therapy

(4) diuretics (? related to kidney disease)

 

where:

The number of central line days ranged from 2 to 7 for patients without CLABSI (median 4).

The number of central line days ranged from 4 to 12 for patients with CLABSI (median 5.5).

 

Factors associated with decreased risk of CLABSI:

(1) myocardial infarction

(2) cholesterol lowering drugs (? related to ischemic heart disease)

(3) antihypertensive therapy

 

Interestingly scores of comorbidity (Charlson, Chronic Disease Score) were not found to be significant.

 

Limitations:

The study was performed at one site.

The number of CLABSI cases was limited (76 cases).


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