Morabito et al developed a simple score for predicting progression-free survival for a patient with Binet Stage A Chronic Lymphocytic Leukemia (CLL). This can help to identify a patient who may or may not benefit from more aggressive management. The authors are from multiple institutions in Italy.
Patient selection: CLL, Binet Stage A
Parameters:
(1) CD38 in percent
(2) cells with IGHV mutations in percent
(3) ZAP70 in percent on flow cytometry
Parameter
Finding
Points
CD38
< 30%
0
>= 30%
1
IGHV
>= 2%
0
< 2%
1
ZAP70
<=30%
0
> 30%
1
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the progression-free survival (PFS).
Total Score
Risk Group
Progression-Free Survival at 12 Years
0
low
80%
1
intermediate
50%
2 or 3
high
13%
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