A small percentage of patients with systemic sclerosis develop limb gangrene associated with peripheral vasculopathy. Mihai et al identified risk factors for this complication. The authors are from multiple institutions in Europe.
Patient selection: systemic sclerosis
Outcome: limb gangrene
Frequency: about 9% in study cohort
The most significant risk factor is a history of digital ulcer, with odds ratio of 38.4.
Other risk factors for gangrene:
(1) history of digital gangrene
(2) diffuse cutaneous subset (dcSSc, OR 2.5)
(3) older age
(4) longer disease duration
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