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Risk Factors of Metintas et al for Poor Prognosis in a Patient with Diffuse Malignant Pleural Mesothelioma

Description

Metintas et al identified a number of risk factors for poor prognosis in a patient with a diffuse malignant pleural mesothelioma. These can help identify a patient who may benefit from more aggressive management. The authors are from Osmangazi University in Eskisehir, Turkey, and Llandough Hospital in Cardiff, UK.


 

Parameters identified on multivariate analysis:

(1) age

(2) clinical tumor stage

(3) Karnofsky performance scale

(4) serum LDH

Parameter

Finding

Points

age of the patient

< 75 years

0

 

>= 75 years of age

1

clinical tumor stage

I

0

 

II, III, or IV

1

Karnofsky performance scale

>= 70

0

 

< 70

1

serum LDH

< 500 IU/L

0

 

>= 500 IU/L

1

 

where:

• The risk ratios ranged from 1.7 to 2.6.

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the greater the risk of a poor outcome.

 

Limitations:

• The authors did not specify the method, instrument or normal reference range for the serum LDH.

 


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