Common SMNs are:
(1) bone sarcomas (associated with radiation therapy)
(2) soft tissue sarcoma
(3) acute leukemia
(4) malignant lymphoma (Hodgkin's or non-Hodgkin's)
(5) skin cancer (malignant melanoma, squamous cell carcinoma, other)
(6) malignant brain tumors
(7) thyroid carcinoma
(8) breast carcinoma
Risk factors for secondary malignant neoplasms:
(1) longer duration of survival
(2) tumor associated with a genetic susceptibility to cancer
(3) family history of cancer
(4) high dose radiation therapy
(5) high dose chemotherapy with anthracyclines and certain other agents
A genetic susceptibility to cancer can be seen with:
(1) retinoblastoma
(2) neurofibromatosis
(3) nevoid basal cell carcinoma
(4) xeroderma pigmentosa
Some patients may develop an SMN without any known risk factors.
