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Risk Factors of Maze et al for Intracranial Hemorrhage in an Adult with Acute Leukemia

Description

Maze et al reported risk factors for intracranial hemorrhage for an adult with acute leukemia. These can help to identify a patient who may require more aggressive management to avoid this complication. The authors are from Princess Margaret Cancer Centre and University Health Network Toronto.


Patient selection: adult with acute leukemia

 

Risk factors for intracranial hemorrhage:

(1) greater leukocytosis (mean 84.5 * 10^9/L vs 28.7 * 10^9/L)

(2) older age (use > 60 years)

(3) diabetes mellitus

(4) high peripheral absolute blast count (mean 61.3 * 10^9/L vs 21.2 * 10^9/L)

(5) prolonged PT in seconds (> 16 seconds)

 

Platelet parameters (count, refractory status, number of days with thrombocytopenia) were not risk factors for intracranial bleeding.


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