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Risk Factors of Mariani et al for Lymph Node Metastasis in a Patient with Endometrial Carcinoma

Description

Mariani et al identified histologic findings associated with lymph node metastases in patients with endometrial carcinoma. This can help identify patients who may benefit from lymph node sampling to determine therapy and prognosis. The authors are from the Mayo Clinic.


 

Parameters:

(1) histologic type of cancer

(2) p53 staining

(3) bcl-2 staining

Parameter

Finding

Points

histologic type of cancer

endometrioid

0

 

non-endometrioid

1

p53 staining

< 33%

0

 

>= 33%

1

bcl-2 staining

1+, 2+, 3+

0

 

completely negative

1

 

number of risk factors associated with nodal metastasis =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

• The higher the score the greater the risk of lymph node metastasis.

 

Total Score

Risk of Metastasis to Lymph Nodes

0

6%

1

13-17%

2

28 - 34%

3

55%

 


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Specialty

ICD-10