Linder et al identified risk factors for intraventricular hemorrhage (IVH) in a very low birth weight (VLBW) premature infant. These can help to identify a neonate who may benefit from more aggressive management. The authors are from Schneider Children's Medical Center of Israel and Sackler School of Medicine in Israel.


Patient selection: very low birth weight infant (< 1,500 g)


Outcome: intraventricular hemorrhage, grade 3 or 4


Risk factors from multivariate analysis:

(1) early sepsis (odds ratio 8.2)

(2) in vitro fertilization or other fertilization treatment (odds ratio 4.3)

(3) no antenatal doses of corticosteroids (odds ratio 0.52 per dose)

(4) not having a low PaCO2 during first 24 hours (odds ratio 0.9 for low PaCO2)


Additional factors noted on the univariate analysis:

(1) high FIO2 during first 24 hours

(2) pneumothorax

(3) lower number of suctionings (higher number protective)

(4) lower first hematocrit (higher first hematocrit protective)


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