Leenderste et al identified risk factors for preventable medication-related hospital admissions at multiple hospitals. These can help to identify a patient who may benefit from an intervention to reduce a readmission. The authors are from Utrecht University, Erasmus Medical Center and multiple hospitals in The Netherlands.

NOTE: This is for hospital admission, not re-admission.


Patient selection: preventable medication-related hospital admission, age > 18 years with two thirds > 65 years of age


Most common reasons for admission:

(1) GI bleeding

(2) other GI tract problems

(3) circulatory system problem (heart failure, arrhythmia, etc)

(4) respiratory tract problem

(5) endocrine or metabolic (hypo or hyperglycemia, hyponatremia, etc)


Key risk factors:

(1) impaired cognition (odds ratio 11.9)

(2) polypathology (>= 4 comorbid conditions, odds ratio 8.1)


Additional risk factors (odds ratios 2.3 to 3.0)

(3) polypharmacy (>= 5 medications chronically used)

(4) physical dependency (affecting activities of daily living)

(5) impaired renal function

(6) nonadherence to medication regimen (based on medication refill rate)

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