Description

Lam et al identified risk factors for the occurrence of malignant melanoma in a patient with a history of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). These can identify a patient who may benefit from more aggressive management. The authors are from the National Cancer Institute (NCI), the George Washington University, Oklahoma City Veterans Affairs Health Care System and Hadassah University Hospital.


 

Patient selection: history of CLL and/or SLL

 

Outcome: malignant melanoma

 

Risk factors for malignant melanoma:

(1) therapy with fludarabine, especially if given with rituximab

(2) presence of a T-cell activating disorder before or after CLL or SLL

 

T-cell activating conditions include:

(1) ankylosing spondylitis

(2) dermatomyositis

(3) polymyalgia rheumatic

(4) sarcoidosis

(5) systemic sclerosis (scleroderma) or localized scleroderma

(6) rheumatic fever or chronic rheumatic heart disease

(7) giant cell arteritis

(8) systemic vasculitis

(9) autoimmune Addison’s disease

(10) Graves’s disease

(11) primary biliary cirrhosis (PBC)

(12) alopecia areata

(13) dermatitis herpetiformis

(14) psoriasis

(15) celiac disease

(16) Crohn’s disease

(17) ulcerative colitis

(18) amyotrophic sclerosis

(19) multiple sclerosis

(20) asthma

 


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