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Risk Factors of Kyriakou et al Affecting Overall Survival for a Patient Waldenstrom’s Macroglobulinemia Following Autologous Stem Cell Transplantation

Description

Kyriakou et al identified a number of factors impacting overall survival for a patient with Waldenstrom’s macroglobulinemia (WM) who underwent autologous stem cell transplantation. These can help to identify those patients who may require more aggressive management. The authors are from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation.


 

Patient selection: WM undergoing autologous stem cell transplant

 

Parameters:

(1) gender

(2) number of treatments preceding the stem cell transplant

(3) age in years

(4) responsiveness to chemotherapy

Parameter

Finding

Points

gender

female

0

 

male

1

number of preceding treatments

0 to 2

0

 

3 or more

1

age in years

<= 50 years

0

 

> 50 years

1

response to chemotherapy

sensitive (achieves complete or partial response)

0

 

chemoresistant

1

 

where:

• The odds ratios ranged from 1.9 to 3.1.

 

total number of poor prognostic factors =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 4

• Overall survival declines as the number of risk factors increases.

 


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