Klatte et al evaluated pediatric patients who developed central line-associated bloodstream infection (CLABSI) caused by Candida species. The authors are from Children's Mercy Hospitals and the University of Missouri-Kansas City.
Candida species isolated included:
(1) C. albicans
(2) C. glabrata
(3) C. krusei
(4) C. tropicalis
(5) C. parapsilosis
(6) C. lusitaniae
Risk factors for Candida CLABSI from a multivariate analysis:
(1) intestinal failure or short gut syndrome (odds ratio 6.8)
(2) gastrostomy tube in place (odds ratio 4.2)
(3) preceding total parenteral nutrition (TPN, odds ratio 3.9)
(4) preceding blood transfusion (odds ratio 3.0)
(5) NICU (odds ratio 3.6)
(6) permanent central catheter (odds ratio 2.6)
Significant observations:
(1) The mortality rate was 3.5 times greater than for those without the Candida CLABSI.
(2) Non-albicans species may be resistant to amphotericin B or fluconazole.
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