Kim et al identified risk factors for wake-up stroke (WUS). The authors are from Seoul National University, Asian Medical Center, Korea University Guro Hospital, Bucheon St. Mary's Hospital and Memorial Hermann of Texas Medical Center.

Wake-up stroke is defined as neurological symptoms first noted upon awakening.


Risk factors:

(1) nocturnal oxygen desaturation (odds ratio 2.9)

(2) hyperlipidemia (odds ratio 1.8)


Nocturnal oxygen desaturation was defined as >= 5 oxygen desaturation events per hour (total number of events divided by time interval in hours). An oxygen desaturation event was when the oxygen saturation in percent minus baseline oxygen saturation >= 3%.


The nocturnal oxygen desaturation may be associated with sleep-disordered breathing. The use of continuous positive airway pressure may protect against nocturnal oxygen desaturation and therefore may help to prevent WUS.

To read more or access our algorithms and calculators, please log in or register.