Keller et al identified risk factors for adverse drug events for a patient receiving outpatient parenteral antimicrobial therapy (OPAT). These can help to identify a patient who may benefit from more aggressive management. The authors are from the Johns Hopkins University.

Patient selection: outpatient parenteral antibiotic therapy


Criteria for an adverse event:

(1) change in antimicrobial agent

(2) stopping antimicrobial therapy early

(3) readmission due to adverse drug event

(4) Clostridium difficile disease


Risk factors for higher risk of an adverse events:

(1) female sex

(2) therapy with daptomycin or vancomycin

(3) days on OPAT < 14 days


Risk factors for lower risk of an adverse event:

(1) therapy for uncomplicated bacteremia

(2) empiric therapy (not targeting a specific bacteria, fungus or virus)


The findings indicate that the patient should be closely monitored in the 2 weeks after hospital discharge.

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