Risk Factors of Kane-Gill et al for Adverse Drug Events (ADE) in a Critically-Ill Patient

 

Patient selection: critically-ill

 

Risk factors for an adverse drug event:

(1) acute kidney injury

(2) thrombocytopenia (platelet count < 100,000 per µL)

(3) emergency admission

(4) greater number of medications given intravenously

(5) high risk medications

 

A serum albumin < 3.5 g/dL was associated with a reduced risk of ADE.

 

The patient’s drug regimens should be reviewed:

(1) daily (trying to discontinue unnecessary medications)

(2) when medications are started or stopped (looking for drug-drug interactions)

(3) when there is a change in organ function, especially if the organ impacts drug kinetics