Patient selection: non-Hodgkin's lymphoma
Outcome: CNS recurrence
Conditions associated with CSN recurrence in the current study:
(1) Burkitt's lymphoma
(2) lymphoblastic lymphoma
(3) high-grade non-Hodgkin's lymphoma with >= 4 of 5 risk factors (see below)
Risk factors:
(1) age > 60 years (odds ratio 2.8)
(2) serum LDH >= 450 U/L (reference range not given; odds ratio 2.1)
(3) serum albumin < 35 g/L (odds ratio 2.5)
(4) retroperitoneal lymph node involvement (odds ratio 1.9)
(5) involvement of >= 2 extranodal sites (odds ratio 3.0)
The authors recommended CNS prophylaxis based on previous studies for involvement of:
(1) testes with Stage >= IIE
(2) paranasal sinuses)
The risk of CNS recurrence in low-grade non-Hodgkin's lymphoma was too low to recommend CNS prophylaxis.
