Hampshire et al evaluated risk factors for mortality for a patient with a hematological malignancy admitted to an intensive care unit (ICU). These can help to identify a patient who may benefit from more aggressive management. The authors are from Royal Liverpool University Hospital, Intensive Care Audit and Research Centre, and Milton Keynes Hospital in England.


Patient selection: adult with hematological malignancy admitted to hospital


Major risk factors for mortality:

(1) multi-organ failures (70% mortality with 2 organ failures, 100% with 4)

(2) in-hospital for >= 20 days before admission to ICU

(3) anemia with hematocrit < 46%

(4) systolic hypotension (< 50 mm Hg)

(5) Glasgow coma score <= 5


Additional risk factors:

(1) history of bone marrow transplant

(2) Hodgkin's disease

(3) sepsis

(4) tachypnea

(5) tachycardia

(6) abnormal arterial pH (acidosis or alkalosis)

(7) abnormal serum sodium (hyper or hyponatremia)

(8) hypoxemia

(9) oliguria

(10) uremia

(11) use of sedation

(12) need for vasopressors



• Older age was listed as a risk factor but the data in Table 4 shows a fairly tight clustering for age and percentage of deaths.


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