A patient with the velocardiofacial syndrome (DiGeorge Syndrome, microdeletion 22q11.2) may develop a number of complications, including psychiatric disorders. Gothelf et al identified risk factors for psychosis in these patients. The authors are Schneider Children's Medical Center of Israel, Tel Aviv University, Stanford University, University of Washington at Seattle, and the University of Geneva.


The development of a psychotic disorder in these patients usually shows a slow evolution that only becomes manifest in late adolescence or early adulthood.


Risk factors for the presence of a psychotic disorder during adolescence:

(1) obsessive compulsive disorder (OCD)

(2) other anxiety and/or depressive disorder

(3) subthreshold psychotic symptoms

(4) lower baseline verbal IQ

(5) catechol o-methyl transferase (COMT) Val108/158Met polymorphism (rs165688)


A patient with one or more of these risk factors should be monitored more closely over time.


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