Risk Factors of Garcia-Vidal et al for Multi-Drug Resistant Pseudomonas aeruginosa Causing Bloodstream Infection (BSI) in a Patient with Acute Leukemia
Garcia-Vidal et al identified patients with acute leukemia who developed bloodstream infections caused by Pseudomonas aeruginosa. They identified risk factors for infection caused by multi-drug resistant strains. The authors are from the University of Barcelona, University of Grand Canary Island and multiple clinics in Spain.
Patient selection: acute leukemia with Pseudomonas aeruginosa bloodstream infection (BSI)
A multi-drug resistant Pseudomonas is resistant to 3 or more of the following:
(1) carbapenems
(2) ureidopenicillins
(3) cephalosporins
(4) monobactams
(5) aminoglycosides
(6) fluoroquinolones
Risk factors for infection with a multi-drug resistant strain:
(1) prior therapy with an antipseudomonal cephalosporin (odds ratio 9.3)
(2) current use of a beta-lactam antibiotic (odds ratio 2.0)
(3) shock (odds ratio 2.6)
(4) pulmonary source of the infection (Pseudomonal pneumonia, odds ratio 9.6)
The mortality of the patient was high if inappropriate therapy was used to treat the infection.
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