Fujimoto et al identified risk factors for liver metastases in a patient with colorectal carcinoma. This can help identify patients who should be screened for hepatic lesions. The authors are from the National Cancer Center Hospital and Research Institute in Tokyo.
Risk factors for liver metastases:
(1) depth of invasion reaching the serosa/peritoneum or into an adjacent organ (beyond the subserosa = T4 in TNM classification)
(2) venous invasion
(3) lymph node metastasis
(4) expression of CD10 on immunoperoxidase stains
The odds ratios ranged from 2 (for CD10 expression) to 3.6 (for depth of invasion)
Parameter |
Findings |
Points |
depth of invasion |
in situ to into subserosa |
0 |
|
to serosa or into adjacent organ (T4 in TNM) |
1 |
venous invasion |
absent |
0 |
|
present |
1 |
lymph node metastases |
absent (N0 in TNM) |
0 |
|
present |
1 |
expression CD10 |
negative |
0 |
|
positive |
1 |
total number of risk factors =
= SUM(points for all 4 risk factors)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 4
Specialty: Hematology Oncology, Surgery, general, Gastroenterology
ICD-10: ,