Fu et al evaluated older adults with Acinetobacter baumanii bacteremia in China. They identified risk factors for extensive drug resistance and for mortality. The authors are from FuXing Hospital and Capital Medical University in Beijing.
Patient selection: adult > 65 years of age with Acinetobacter baumanii bacteremia
Resistance
Resistant to
multidrug (MDR)
>= 3 of the following: aminoglycosides, antipseudomonal penicillin and beta-lactamase inhibitor combination, antipseudomonal carbapenema, antipseudomonal fluoroquinolones, trimethoprim-sulfamethoxazole, cephalosprins, ampicillin-sulbactam, polymyxins, tetracyclines
extensive (XDR)
all of the antibiotics listed above except polymyxins and tigecycline
carbapenem (CR)
imipenem or meropenem
Risk factors for extensive drug resistance:
(1) COPD
(2) bedridden
(3) central venous catheter
Risk factors for mortality:
(1) extensive drug resistance
(2) in the ICU
(3) concurrent fungal infection
(4) age >= 70 years
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