Description

Fry et al identified risk factors for mortality in patients with intra-abdominal abscess. This can help identify patients who may benefit from more aggressive therapy. The authors are from the University of Louisville in Kentucky.


 

Locations of intra-abdominal abscesses (from Table III, page 520):

(1) subphrenic space

(2) pelvic space

(3) subhepatic space

(4) paracolic gutter

(5) lesser sac

(6) subfascial

 

Organ failures (Table IV, page 520):

(1) respiratory

(2) hepatic

(3) renal

(4) stress gastrointestinal hemorrhage (coagulation)

 

Risk factors for mortality:

(1) age > 50 years (p < 0.03)

(2) one or more organ failure(s) (p < 0.001), with risk increasing for each organ failure

(3) positive blood culture (p < 0.01)

(4) lesser sac abscess (p < 0.001)

(5) subhepatic abscess (p < 0.03)

(6) recurrent and/or persistent abscess (p < 0.01)

(7) multiple abscesses (p < 0.01)

 

Processes involved in:

(1) inadequate surgical drainage

(2) host defense and organ failures

 

where:

• I assume cardiac, neurologic and hematologic failures could also be included as organ failures.

• Immunodeficiency and immunosuppression were not listed as risk factors but may not have been present in the study population (143 general surgical patients).

• I would have expected that diabetes mellitus would contribute to increased mortality. This may be represented as failure to clear an abscess (recurrent or persistent).

 


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