A patient with Crohn's disease has an increased risk for gallstone disease. Fraquelli et al identified factors that were related with the increased risk in 330 consecutive patients. The authors are from IRCCS Ospedale Maggiore in Milan and Ospedale A. Manzoni in Lecco, Italy.
Parameters associated with an increased risk:
(1) age
(2) site of Crohn's disease at diagnosis
(3) bowel resection and number
(4) site of bowel resection
|
Parameter |
Finding |
Odds Ratio |
95% Confidence Interval |
|
age |
<= 44 |
1 |
|
|
|
45 – 59 |
3.14 |
1.68 – 5.85 |
|
|
>= 60 |
6.77 |
3.04 – 15.00 |
|
site at diagnosis |
ileal |
1 |
|
|
|
ileocecal |
2.93 |
1.32 – 6.51 |
|
|
ileal and colonic |
1.28 |
0.64 – 2.55 |
|
|
colonic |
2.16 |
0.89 – 5.23 |
|
bowel resection |
none |
1 |
|
|
|
1 |
1.63 |
0.85 – 3.09 |
|
|
2 |
5.41 |
2.34 – 12.50 |
|
site of bowel resection |
none |
1 |
|
|
|
ileal |
2.15 |
0.97 – 4.74 |
|
|
ileocecal |
4.83 |
2.18 – 10.70 |
|
|
ileal and colonic |
1.35 |
0.61 – 3.02 |
|
|
colonic |
3.18 |
0.99 – 10.10 |
from Table 2, page 2203
where:
• My reading of the paper suggests that the age-related risk indicates a history of current or previous gallstone disease. Thus, a person 65 years of age is more likely to give a history of gallstone disease than a person who is 45 years of age.
Specialty: Gastroenterology, Surgery, general
ICD-10: ,
