Risk Factors of Ficarra et al for Metastases to Nonpalpable Inguinal Lymph Nodes in a Patient with Squamous Cell Carcinoma of the Penis

Description

Ficarra et al identified risk factors for metastases in nonpalpable inguinal lymph nodes in men with squamous cell carcinoma of the penis. This can help identify patients who may benefit from closer monitoring and more aggressive management. The authors are from multiple university hospitals in Italy.

Patient selection: Men with squamous cell carcinoma of the penis and nonpalpable inguinal lymph nodes.

Parameters identified on multivariate analysis:

(1) corpus spongiosum and/or urethra involvement

(2) venous and/or lymphatic tumor embolization (intravascular tumor spread)

Parameter	Finding	Points
invasion of corpus cavernosum and/or urethra	absent	0
	present	1
venous and/or lymphatic tumor emboli	absent	0
	present	1

where:

• The hazard ratio for invasion of the corpus spongiosum and/or urethra was 3.6 (95% CI 1.3 to 16.1).

• The hazard ratio for intravascular tumor spread was 5.4 (95% CI 1.4 to 21.1)

Number of Factors Present	Risk of Metastases
0	low
1	moderate
2	high

The presence of Grade 2 or 3 histologic differentiation was associated with increased risk of metastases but this had a p value of 0.06.

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Description

Specialty

ICD-10