Faller et al identified risk factors for mortality in an older adult with acute venous thromboembolism. These can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Switzerland.

Patient selection: age >= 65 years with acute venous thromboembolism


Outcome: mortality in the following 30 months (from cancer, pulmonary embolism, infection, bleeding or other cause)


Advancing age was associated with increased mortality, especially if the age is >= 75 years.


Risk factors for mortality with hazard ratio 2.8 to 5.8:

(1) active cancer

(2) systolic blood pressure < 100 mm Hg


Risk factors for mortality with hazard ratios from 1.4 to 1.9:

(1) diabetes mellitus

(2) low physical activity

(3) polypharmacy

(4) anemia

(5) C-reactive protein > 40 mg/L

(6) ultra-sensitive serum troponin > 14 pg/mL

(7) D-dimer > 3,000 ng/mL

To read more or access our algorithms and calculators, please log in or register.