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Risk Factors of Erbil et al for Hypocalcemic Following Total Thyroidectomy for Nontoxic Multinodular Goiter

Description

Erbil et al evaluated risk factors associated with postoperative hypocalcemia following total thyroidectomy for nontoxic multinodular goiter. This can help identify patients who may benefit from calcium or vitamin D supplementation following the operation. The authors are from Istanbul University in Turkey.


 

Criteria for postoperative hypocalcemia: serum total calcium <= 8.0 mg/dL

 

Parameters:

(1) age of the patient in years

(2) postoperative parathyroid hormone in pg/mL

(3) preoperative serum 25-hydroxyvitamin D3 in ng/mL

 

If the preoperative serum 25-hydroxyvitamin D3 is < 15 ng/mL then there is a high rate (odds ratio 559) of postoperative hypocalcemia. These patients should be targeted for aggressive management to minimize hypocalcemia after total thyroidectomy.

 

Additional risk factors associated with a risk for postoperative hypocalcemia:

(1) age > 50 years

(2) postoperative parathyroid hormone < 10 pg/mL

 

Reference ranges:

(1) total serum calcium: 8.5 to 10.5 mg/dL

(2) parathyroid hormone: 10 to 65 pg/mL

(3) 25-hydroxyvitamin D3: 6 to 46 ng/mL

 


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Specialty

ICD-10